Creating context for the use of DNA adduct data in cancer risk assessment: I. Data organization
Jarabek, AM; Pottenger, LH; Andrews, LS; Casciano, D; Embry, MR; Kim, JH; Preston, RJ; Reddy, MV; Schoeny, R; Shuker, D; Skare, J; Swenberg, J; Williams, GM; Zeiger, E
HERO ID
710787
Reference Type
Journal Article
Subtype
Review
Year
2009
Language
English
PMID
| HERO ID | 710787 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2009 |
| Title | Creating context for the use of DNA adduct data in cancer risk assessment: I. Data organization |
| Authors | Jarabek, AM; Pottenger, LH; Andrews, LS; Casciano, D; Embry, MR; Kim, JH; Preston, RJ; Reddy, MV; Schoeny, R; Shuker, D; Skare, J; Swenberg, J; Williams, GM; Zeiger, E |
| Journal | Critical Reviews in Toxicology |
| Volume | 39 |
| Issue | 8 |
| Page Numbers | 659-678 |
| Abstract | The assessment of human cancer risk from chemical exposure requires the integration of diverse types of data. Such data involve effects at the cell and tissue levels. This report focuses on the specific utility of one type of data, namely DNA adducts. Emphasis is placed on the appreciation that such DNA adduct data cannot be used in isolation in the risk assessment process but must be used in an integrated fashion with other information. As emerging technologies provide even more sensitive quantitative measurements of DNA adducts, integration that establishes links between DNA adducts and accepted outcome measures becomes critical for risk assessment. The present report proposes an organizational approach for the assessment of DNA adduct data (e.g., type of adduct, frequency, persistence, type of repair process) in concert with other relevant data, such as dosimetry, toxicity, mutagenicity, genotoxicity, and tumor incidence, to inform characterization of the mode of action. DNA adducts are considered biomarkers of exposure, whereas gene mutations and chromosomal alterations are often biomarkers of early biological effects and also can be bioindicators of the carcinogenic process. |
| Doi | 10.1080/10408440903164155 |
| Pmid | 19743944 |
| Wosid | WOS:000270810500002 |
| Url | <Go to ISI>://WOS:000270810500002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000270810500002 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Biomarkers; cancer; DNA adducts; mode of action; risk assessment |
| Is Qa | No |