Apoptosis inducing and enhancing activities of environmental estrogenic compounds
Beppu, M; Nakadai, Y; Igarashi, Y
HERO ID
746794
Reference Type
Journal Article
Year
2006
Language
English
| HERO ID | 746794 |
|---|---|
| In Press | No |
| Year | 2006 |
| Title | Apoptosis inducing and enhancing activities of environmental estrogenic compounds |
| Authors | Beppu, M; Nakadai, Y; Igarashi, Y |
| Journal | Journal of Health Science |
| Volume | 52 |
| Issue | 6 |
| Page Numbers | 831-837 |
| Abstract | Effects of estrogenic compds. (bisphenol A, alkyl phenols, phthalate esters, and genistein) on T lymphocyte apoptosis were investigated in vitro. The assays were performed in the absence or presence of low concns. of apoptosis-inducing agents etoposide or dexamethasone to detect apoptosis-inducing, -enhancing, and -suppressing activities of the test compds. When T lymphatic Jurkat cells were exposed to 10 ?M bisphenol A for 20 h, apoptosis was not induced, but apoptosis induced by 1 ?M etoposide was significantly enhanced. The 4-n-Nonylphenol (10 ?M) showed an apoptosis-inducing activity significantly. The 4-tert-Octylphenol (10 ?M) exhibited an apoptosis-enhancing activity. In contrast, phthalate esters including di-Bu phthalate and di-2-ethylhexyl phthalate showed neither activity at 10 ?M. Genistein (10 ?M) significantly exhibited apoptosis-inducing and enhancing activities. On the other hand, 17?-estradiol did not show any of these activities at 10 nM, the concn. exerting the estrogenic activity comparable to or much higher than that of 10 ?M of the test compds. Effects of these estrogenic compds. on apoptosis were also investigated using mouse primary thymocytes. Mouse thymocytes similarly exposed to the estrogenic compds. in the absence or the presence of dexamethasone for 6 h were characterized. In agreement with Jurkat cells, apoptosis-inducing or/and -enhancing activities were obsd. for the cells coincubated with bisphenol A, alkyl phenols, and genistein, but not those with di-2-ethylhexyl phthalate or 17?-estradiol. The apoptosis-inducing or/and -enhancing effects of the estrogenic compds. obsd. here appear to be due to their unidentified properties other than estrogenic activity. |
| Doi | 10.1248/jhs.52.831 |
| Wosid | WOS:000243148200028 |
| Url | https://search.proquest.com/docview/1443491216?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000243148200028 |
| Is Public | Yes |
| Language Text | English |
| Keyword | apoptosis; endocrine disruptor; estrogenic compound; T lymphocyte; thymocyte |
| Is Qa | No |