Chronic inhalation effects of trichloroethylene on hepatic microsomal mixed function oxidase system in rats
Soni, MG; Nomiyama, H; Nomiyama, K
| HERO ID | 75422 |
|---|---|
| In Press | No |
| Year | 1990 |
| Title | Chronic inhalation effects of trichloroethylene on hepatic microsomal mixed function oxidase system in rats |
| Authors | Soni, MG; Nomiyama, H; Nomiyama, K |
| Journal | Toxicological and Environmental Chemistry |
| Volume | 29 |
| Issue | 2 |
| Page Numbers | 121-126 |
| Abstract | Inhalation effects of trichloroethylene, at levels of 0, 200 and 600 ppm for a period of 4 and 12 weeks, on the contents of hepatic microsomal protein, cytochrome P sub(450), cytochrome b sub(5), and on the activities of NADPH cytochrome C reductase, aminopyrine N-demethylase and aniline hydroxylase were investigated. Body weight remained unaltered at 200 ppm level, whereas at 600 ppm level a significant decrease in body weight was observed. Liver weight showed increases at an exposure level of 200 ppm by the end of 4 and 12 weeks. Relative liver weight (% body weight) showed an increase at 200 and 600 ppm level by the end of week 4, whereas, after 12 weeks increase was observed only in animals exposed to the 600 ppm level. Hepatic microsomal protein was decreased by the end of 4 weeks at both the exposure levels. Cytochrome P sub(450) and cytochrome b sub(5) contents were increased at the 200 ppm level after 4 and 12 weeks. NADPH cytochrome C reductase activity showed a marked increase at both the 200 and 600 ppm levels after 4 and 12 weeks. |
| Doi | 10.1080/02772249009357626 |
| Wosid | WOS:A1990FR21400007 |
| Url | https://www.proquest.com/scholarly-journals/chronic-inhalation-effects-trichloroethylene-on/docview/16017433/se-2?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Toxicol. Environ. Chem. 29: 121-126. |
| Is Public | Yes |
| Language Text | English |
| Keyword | TRICHLOROETHYLENE; MICROSOMAL MIXED FUNCTION OXIDASE SYSTEM |
| Is Qa | No |