Comparison of pulmonary responses of asthmatic and nonasthmatic subjects performing light exercise while exposed to a low level of ozone
Horstman, DH; Ball, BA; Brown, J; Gerrity, T; Folinsbee, LJ
HERO ID
75834
Reference Type
Journal Article
Year
1995
Language
English
PMID
| HERO ID | 75834 |
|---|---|
| In Press | No |
| Year | 1995 |
| Title | Comparison of pulmonary responses of asthmatic and nonasthmatic subjects performing light exercise while exposed to a low level of ozone |
| Authors | Horstman, DH; Ball, BA; Brown, J; Gerrity, T; Folinsbee, LJ |
| Journal | Toxicology and Industrial Health |
| Volume | 11 |
| Issue | 4 |
| Page Numbers | 369-385 |
| Abstract | To determine if asthmatic subjects (ASTH, n = 17) experience greater O-3-induced pulmonary decrements than nonasthmatic subjects (NONA, n = 13), both groups were exposed for 7.6 h to both clean air and 0.16 m O-3. Exposures consisted of seven 50-min periods of light exercise (V-E = 14.2 and 15.3 l/min/m(2) for ASTH and NONA, respectively), each followed by 10 min rest. A 35-min lunch period followed the third exercise. Following O-3 exposure, decrements in forced expiratory volume in one second (FEV(1)) and FEV(1) divided by forced viral capacity (FVC), corrected for air exposure, for ASTH (-19.4 +/- 3.1 % and 6.2 +/- 2%, respectively) were significantly greater (p = 0.04 and 0.02) than for NONA (-9.8 +/- 1.9% and -1 +/- 1%, respectively). There was no difference (p = 0.33) for decrements in FVC between ASTH (-11.8 +/- 1.9%) and NONA (-8.8 +/- 2.1%). Nine of 17 ASTH experienced wheezing with O-3, while only one experienced wheezing with air (p = 0.004); no NONA experienced wheezing. Six of 17 ASTH requested inhaled P-agonist bronchodilator prior to and/or during O-3 exposure and experienced some temporary alleviation of decrements. At end exposure, however, ASTH who were medicated had greater Os-induced decrements than those who were not medicated. ASTH who had the larger Os-induced decrements had lower baseline FEV(1)/FVC and lower baseline %predicted FEV(1). These data indicate that in ASTH, unlike NONA, some portion of O-3-induced pulmonary decrements experienced was related to bronchoconstriction, and that O-3-responsiveness for ASTH depended upon baseline airway status. |
| Doi | 10.1177/074823379501100401 |
| Pmid | 8748419 |
| Wosid | WOS:A1995TK62900001 |
| Url | http://tih.sagepub.com/cgi/doi/10.1177/074823379501100401 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.Toxicol. Ind. Health 11: 369-385. |
| Is Public | Yes |
| Language Text | English |
| Keyword | asthma; light exercise; ozone; prolonged exposure; pulmonary function;HOSPITAL ADMISSIONS; AIR-POLLUTION; MODERATE EXERCISE; SOUTHERN ONTARIO; UNITED-STATES; 0.12 PPM; HEALTHY |
| Is Qa | No |