Decrease in hepatotoxicity by lead exposure is not explained by its mitogenic response
Calabrese, EJ; Baldwin, LA; Leonard, DA; Zhao, XQ
HERO ID
77651
Reference Type
Journal Article
Year
1995
Language
English
PMID
| HERO ID | 77651 |
|---|---|
| In Press | No |
| Year | 1995 |
| Title | Decrease in hepatotoxicity by lead exposure is not explained by its mitogenic response |
| Authors | Calabrese, EJ; Baldwin, LA; Leonard, DA; Zhao, XQ |
| Journal | Journal of Applied Toxicology |
| Volume | 15 |
| Issue | 2 |
| Page Numbers | 129-132 |
| Abstract | The present research was conducted to evaluate the effect of mitogen pre-exposure on CCl4-induced hepatotoxicity. Male Wistar rats were administered a single i.p. injection of CCl4 (0.3 ml kg-1 in corn oil) 48 h following either a single dose of lead nitrate (0.33 mg kg-1) or distilled water via i.v. injection. Hepatotoxicity, as measured by serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, was monitored 6, 24, 48, 72 and 120 h after CCl4 exposure. The lead nitrate-pretreated rats displayed markedly lower serum ALT and AST levels at 24, 48 and 72 h than rats pretreated with distilled water. However, treatment with the antimitotic agent colchicine did not alter the lead-induced protection. These findings suggest that the lead-induced protection is not associated with the major mitogenic response of lead, despite its strong temporal association. A critical review of the available toxicological data also argues against the lead protection being a function of its capacity to inhibit cytochrome P-450. |
| Doi | 10.1002/jat.2550150212 |
| Pmid | 7782558 |
| Wosid | WOS:A1995QP84700010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | J. Appl. Toxicol. 15: 129-132. |
| Is Public | Yes |
| Language Text | English |
| Keyword | MITOGENICITY; LEAD NITRATE; HEPATOTOXICITY; CARBON TETRACHLORIDE; WISTAR RAT; COLCHICINE |
| Is Qa | No |