Vitamin D and autoimmunity: Is vitamin D status an environmental factor affecting autoimmune disease prevalence?
Cantorna, MT
| HERO ID | 80060 |
|---|---|
| In Press | No |
| Year | 2000 |
| Title | Vitamin D and autoimmunity: Is vitamin D status an environmental factor affecting autoimmune disease prevalence? |
| Authors | Cantorna, MT |
| Journal | Experimental Biology and Medicine |
| Volume | 223 |
| Issue | 3 |
| Page Numbers | 230-233 |
| Abstract | The environment in which the encounter of antigen with the immune system occurs determines whether tolerance, infectious immunity, or autoimmunity results. Geographical areas with low supplies of vitamin D (for example Scandinavia) correlate with regions with high incidences of multiple sclerosis, arthritis, and diabetes. The active form of vitamin D has been shown to suppress the development of autoimmunity in experimental animal models. Furthermore, vitamin D deficiency increases the severity of at least experimental autoimmune encephalomyelitis (mouse multiple sclerosis). Targets for vitamin D in the immune system have been identified, and the mechanisms of vitamin D-mediated immunoregulation are beginning to be understood. This review discusses the possibility that vitamin D status is an environmental factor, which by shaping the immune system affects the prevalence rate for autoimmune diseases such as multiple sclerosis, arthritis, and juvenile diabetes. |
| Doi | 10.1046/j.1525-1373.2000.22333.x |
| Pmid | 10719834 |
| Wosid | WOS:000085461900003 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.Proc. Soc. Exp. Biol. Med. 223: 230-233. |
| Is Public | Yes |
| Is Qa | No |