Phase-specific developmental toxicity of monobenzyl phthalate (MBeP) in rats
Ema, M; Harazono, A; Miyawaki, E; Amano, H; Ogawa, Y
HERO ID
812490
Reference Type
Journal Article
Subtype
Abstract
Year
1996
Language
English
| HERO ID | 812490 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1996 |
| Title | Phase-specific developmental toxicity of monobenzyl phthalate (MBeP) in rats |
| Authors | Ema, M; Harazono, A; Miyawaki, E; Amano, H; Ogawa, Y |
| Journal | Toxicologist |
| Volume | 30 |
| Issue | 1 Pt 2 |
| Page Numbers | 189-190 |
| Abstract | In our previous studies, butyl benzyl phthalate (BBP) was found to be teratogenic when administered to rats on days 7-9 and days 13-15 of pregnancy but not days 10-12. The present study was conducted to determine the phase specificity of the developmental toxicity of MBeP, which is one of the major metabolites of BBP, and to assess the role of MBeP in the developmental toxicity of BBP. Pregnant rats were given MBeP by gavage at a dose of 375, 500 or 625 mg/kg on days 7-9, days 10-12 or days 13-15 of pregnancy. A significant increase in embryolethality was noted in pregnant rats given MBeP at 500 mg/kg and above regardless of the days of treatment. No evidence of teratogenicity was found when MBeP was given on days 10-12. A significantly increased incidence of fetuses with external malformations was found after treatment on days 13-15 at 500 mg/kg. A significantly increased incidence of fetuses with skeletal malformations was observed after treatment on days 7-9 at 625 mg/kg and on days 13-15 at 375 mg/kg and above. Deformity of the vertebral column and ribs was predominantly observed after treatment on days 7-9. Cleft palate and fusion of the sternebrae were exclusively found after treatment on days 13-15. The dependence of gestational days of treatment on the manifestation of the developmental toxicity and the spectrum of fetal malformations induced by MBeP were similar to those induced by BBP. These findings suggest that MBeP and/or its further metabolites may be responsible for the production of the developmental toxicity of BBP. |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Authoring Organization: MONSANTO APPLIED SCI DIV |
| Is Public | Yes |
| Language Text | English |
| Keyword | Pregnancy; Rats; Animal; Female; Dose-Response Relationship, Drug; Abnormalities, Drug-Induced; Bone and Bones/ABNORMALITIES; Phthalic Acids/TOXICITY; Phthalic Acids/METABOLISM; 85-68-7; NO CAS RN; 2528-16-7 |
| Is Qa | No |