A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation
Levey, AS; Bosc, JP; Lewis, JB; Greene, T; Rogers, N; Roth, D
HERO ID
81587
Reference Type
Journal Article
Year
1999
Language
English
PMID
| HERO ID | 81587 |
|---|---|
| In Press | No |
| Year | 1999 |
| Title | A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation |
| Authors | Levey, AS; Bosc, JP; Lewis, JB; Greene, T; Rogers, N; Roth, D |
| Journal | Annals of Internal Medicine |
| Volume | 130 |
| Issue | 6 |
| Page Numbers | 461-470 |
| Abstract | BACKGROUND: Serum creatinine concentration is widely used as an index of renal function, but this concentration is affected by factors other than glomerular filtration rate (GFR). OBJECTIVE: To develop an equation to predict GFR from serum creatinine concentration and other factors. DESIGN: Cross-sectional study of GFR, creatinine clearance, serum creatinine concentration, and demographic and clinical characteristics in patients with chronic renal disease. PATIENTS: 1628 patients enrolled in the baseline period of the Modification of Diet in Renal Disease (MDRD) Study, of whom 1070 were randomly selected as the training sample; the remaining 558 patients constituted the validation sample. METHODS: The prediction equation was developed by stepwise regression applied to the training sample. The equation was then tested and compared with other prediction equations in the validation sample. RESULTS: To simplify prediction of GFR, the equation included only demographic and serum variables. Independent factors associated with a lower GFR included a higher serum creatinine concentration, older age, female sex, nonblack ethnicity, higher serum urea nitrogen levels, and lower serum albumin levels (P < 0.001 for all factors). The multiple regression model explained 90.3% of the variance in the logarithm of GFR in the validation sample. Measured creatinine clearance overestimated GFR by 19%, and creatinine clearance predicted by the Cockcroft-Gault formula overestimated GFR by 16%. After adjustment for this overestimation, the percentage of variance of the logarithm of GFR predicted by measured creatinine clearance or the Cockcroft-Gault formula was 86.6% and 84.2%, respectively. CONCLUSION: The equation developed from the MDRD Study provided a more accurate estimate of GFR in our study group than measured creatinine clearance or other commonly used equations. |
| Doi | 10.7326/0003-4819-130-6-199903160-00002 |
| Pmid | 10075613 |
| Wosid | WOS:000079165500001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | San Antonio, TX |
| Conference Name | 30th Annual Meeting of the American Society of Nephrology |
| Conference Date | November 2-6, 1997 |
| Is Public | Yes |
| Language Text | English |