Development of the murine and human immune system: Differential effects of immunotoxicants depend on time of exposure
Holladay, SD; Smialowicz, RJ
HERO ID
84009
Reference Type
Journal Article
Subtype
Review
Year
2000
Language
English
PMID
| HERO ID | 84009 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2000 |
| Title | Development of the murine and human immune system: Differential effects of immunotoxicants depend on time of exposure |
| Authors | Holladay, SD; Smialowicz, RJ |
| Journal | Environmental Health Perspectives |
| Volume | 108 |
| Issue | Suppl 3 |
| Page Numbers | 463-473 |
| Abstract | Fetal and early postnatal life represent critical periods in vertebrate immune system development. Disruption of such development by perinatal immunotoxic chemical exposure has been widely described in experimental animal models. The resultant inhibited postnatal immune responses in such animals are often more dramatic and persistent than those after exposure during adult life. Further, recent reports suggest that prenatal exposure to immunotoxicants may exacerbate postnatal aberrant immune responses (e.g., hypersensitivity disorders and autoimmune disease) in genetically predisposed rodents. Limited information is available regarding the possibility of inhibited postnatal immune capacity in humans as a result of developmental immunotoxicant exposure. The multifactorial nature of hypersensitivity and autoimmune responses will further complicate the elucidation of possible relationships between chemical exposure during ontogeny of the human immune system and immune-mediated disease later in life. Taken together, however, the available animal data suggest the potential for altered postnatal immune function in humans exposed to immunotoxicants (e.g., environmental chemicals and therapeutic agents) during fetal and/or early postnatal life. |
| Doi | 10.2307/3454538 |
| Pmid | 10852846 |
| Wosid | WOS:000087748400017 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033941252&doi=10.1289%2fehp.00108s3463&partnerID=40&md5=e6fbfd938b7355974155e40c09268308 |
| Is Public | Yes |
| Language Text | English |
| Keyword | autoimmune disease; developmental immunotoxicity; diethylstilbestrol; immune development; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; prenatal; therapeutic immunosuppressant |