Biological availability of arsenic from fish
Munro, IC; Charbonneau, SM; Sandi, E; Spencer, K; Bryce, F; Grice, HC
HERO ID
8433
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 8433 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Biological availability of arsenic from fish |
| Authors | Munro, IC; Charbonneau, SM; Sandi, E; Spencer, K; Bryce, F; Grice, HC |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 111 |
| Abstract | Although it has been well established that certain species of marine life contain high amounts of arsenic, little experimental data exists concerning the bioavailability of this arsenic to mammals. In order to gain some information on the potential public hazard, studies were undertaken to compare the excretion of arsenic from fish and arsenic trioxide. Adult female Yorkshire pigs with urinary catheters were given a series of 4 single meals; low arsenic fish (control); high arsenic fish (0.3 mg As/kg); arsenic trioxide (0.3 mg As/kg) and arsenic trioxide with low arsenic fish (0.3 mg As/kg). Urine samples were collected daily for 3 days prior to dosing, every 12 hr for 4 days after dosing and then daily for 6 days. Fecal collections were done daily for 3 days prior to dosing and for JO days thereafter. Following administration of the high arsenic fish, 80% of the arsenic was excreted in the urine and the remaining 20% appeared in the feces. Excretion was virtually complete in 4 days. Following administration of arsenic trioxide, 80% of the arsenic was excreted in the urine in the 1st day, while the remaining 20% appeared to be retained in the body. |
| Wosid | WOS:A1974T653800098 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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