Gene expression of neutrophins and their receptors in lead nitrate-induced rat liver hyperplasia
Nemoto, K; Miyata, S; Nemoto, F; Yasumoto, T; Murai, U; Kageyama, H; Degawa, M
HERO ID
85834
Reference Type
Journal Article
Year
2000
Language
English
PMID
| HERO ID | 85834 |
|---|---|
| In Press | No |
| Year | 2000 |
| Title | Gene expression of neutrophins and their receptors in lead nitrate-induced rat liver hyperplasia |
| Authors | Nemoto, K; Miyata, S; Nemoto, F; Yasumoto, T; Murai, U; Kageyama, H; Degawa, M |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 275 |
| Issue | 2 |
| Page Numbers | 472-476 |
| Abstract | Neurotrophins including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) are known to play important roles in the survival, proliferation, differentiation, and/or maintenance of function in several tissues including neuronal tissues. The role of neurotrophins in liver tissue, however, has not yet been clarified. In the present study, we assessed the temporal change in gene expression of neurotrophins, NGF, BDNF, and NT-3, and their receptors, low affinity neurotrophin receptor (p75NTR) and Trks A, B, and C, by RT-PCR technique in the liver of rats treated with lead nitrate (LN; 0.1 mmol/kg body weight), an inducer of liver hyperplasia. The mRNAs for NGF, BDNF with exon 4, NT-3, p75NTR, and all Trk members were detected in the LN-untreated liver. LN treatment resulted in increases in the levels of NGF, BDNF with exon 4, NT-3, p75NTR, and TrkA mRNAs and further led to expression of BDNF mRNA with exon 3. The increase in gene expression of neurotrophins and their receptors was closely correlated with those in liver weight. In this report, we propose for the first time that neurotrophins may play crucial roles in LN-induced liver hyperplasia. |
| Doi | 10.1006/bbrc.2000.3340 |
| Pmid | 10964689 |
| Wosid | WOS:000089069700037 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.Biochem. Biophys. Res. Commun. 275: 472-476. |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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