Metabolism and disposition of inorganic arsenic in laboratory animals and humans
Mckinney, JD
| HERO ID | 8687 |
|---|---|
| In Press | No |
| Year | 1992 |
| Title | Metabolism and disposition of inorganic arsenic in laboratory animals and humans |
| Authors | Mckinney, JD |
| Journal | Environmental Geochemistry and Health |
| Volume | 14 |
| Issue | 2 |
| Page Numbers | 43-48 |
| Abstract | The carcinogenicity of inorganic arsenic in humans, particularly in the lung and skin, has been reasonably well established through epidemiological investigations. However, there is no substantial experimental evidence for carcinogenicity in animals to suort the human studies. Studies of metabolism and disposition of inorganic arsenic in various animal species are particularly relevant to determining the factors that might account for the lack of an animal model. Numerous studies of this type have been reported, but there do not appear to be clear qualitative or quantitative differences in the overall fate and disposition of inorganic arsenic in most animals versus humans, although little is known at the cellular and subcellular level. Sulphur chemistry, especially thiol status, is emerging as an important regulating factor in the overall fate and distribution of inorganic arsenic in the body, playing a role in the initial reduction of arsenate to arsenite and subsequent methylation, and possibly in determining tissue affinity and distribution properties. The metabolism of inorganic arsenic can be viewed as a redox cycle in which thiol compounds such as glutathione (GSH) possibly function as reducing agents and methyl donors as oxidising agents. One explanation for the possible sensitivity of certain malnourished human populations to the carcinogenic effects of inorganic arsenic may be related to the reduced availability of nonprotein sulphhydryl compounds such as GSH needed to drive the redox cycle and facilitate arsenic detoxification. Future carcinogenicity studies of inorganic arsenic in animals could be designed to address directly this aspect of the problem. |
| Doi | 10.1007/BF01783627 |
| Pmid | 24197925 |
| Wosid | WOS:A1992JF06000004 |
| Url | http://www.springerlink.com/index/10.1007/BF01783627 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Environ. Geochem. Health 14: 43-48. |WOS:A1992JF06000004 |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-Proteins</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-Minerals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Metabolism-Minerals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Respiratory System-Pathology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Integumentary System-Pathology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxicology-General</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Neoplasms and Neoplastic Agents-Carcinogens and Carcinogenesis</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Hominidae</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Muridae</kw> |
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