The role of nitric oxide and cytokines in asthma-like syndrome induced by sulfur dioxide exposure in agricultural environment
Koksal, N; Yildirim, Z; Gokirmak, M; Hasanoglu, HC; Mehmet, N; Avci, H
HERO ID
89920
Reference Type
Journal Article
Year
2003
Language
English
PMID
| HERO ID | 89920 |
|---|---|
| In Press | No |
| Year | 2003 |
| Title | The role of nitric oxide and cytokines in asthma-like syndrome induced by sulfur dioxide exposure in agricultural environment |
| Authors | Koksal, N; Yildirim, Z; Gokirmak, M; Hasanoglu, HC; Mehmet, N; Avci, H |
| Journal | Clinica Chimica Acta |
| Volume | 336 |
| Issue | 1-2 |
| Page Numbers | 115-122 |
| Abstract | BACKGROUND: We previously demonstrated that apricot sulfurization workers are exposed to high concentrations of SO(2), subsequently causing asthma-like syndrome. This study investigated the effects of SO(2) exposure on serum TNF-alpha, IL-1beta, IL-6, IL-8, nitrite and nitrate levels to understand the mechanism of SO(2)-induced bronchoconstriction in asthma-like syndrome. METHODS: We measured the serum levels of the cytokines, direct nitrite, total nitrite and nitrate obtained from 40 volunteer workers after an hour of exposure to SO(2) and 23 healthy controls. RESULTS: The concentrations of the cytokines, direct nitrite, total nitrite and nitrate were significantly (p<0.0001) higher in the workers than in the controls. The mean serum concentrations of TNF-alpha, IL-1beta, IL-6, IL-8, direct nitrite, total nitrite and nitrate were 430.60+/-397.03 pg/ml, 436.67+/-316.31 pg/ml, 752.11+/-394.95 pg/ml, 262.12+/-287.99 pg/ml, 7.75+/-3.34 micromol/l, 115.72+/-48.78 micromol/l and 107.97+/-46.19 micromol/l in the workers, while they were 9.83+/-3.12 pg/ml, <5 pg/ml, 7.49+/-1.27 pg/ml, 9.38+/-1.99 pg/ml, 2.17+/-0.77 micromol/l, 59.91+/-7.56 micromol/l and 57.74+/-7.20 micromol/l in the controls, respectively. CONCLUSION: These results show that TNF-alpha, IL-1beta, IL-6, IL-8 and nitric oxide may play a role in the pathogenesis of bronchoconstriction in asthma-like syndrome due to the SO(2) exposure. |
| Doi | 10.1016/S0009-8981(03)00334-6 |
| Pmid | 14500043 |
| Wosid | WOS:000185809400016 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.Clin. Chim. Acta 336: 115-122. |
| Is Public | Yes |
| Language Text | English |
| Keyword | sulfur dioxide; bronchoconstriction; cytokines; nitric oxide |
| Is Peer Review | Yes |