Methyl tertiary-butyl ether mode of action for cancer endpoints in rodents
Cruzan, G; Borghoff, SJ; de Peyster, A; Hard, GC; McClain, M; McGregor, DB; Thomas, MG
HERO ID
90116
Reference Type
Journal Article
Subtype
Review
Year
2007
Language
English
PMID
| HERO ID | 90116 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2007 |
| Title | Methyl tertiary-butyl ether mode of action for cancer endpoints in rodents |
| Authors | Cruzan, G; Borghoff, SJ; de Peyster, A; Hard, GC; McClain, M; McGregor, DB; Thomas, MG |
| Journal | Regulatory Toxicology and Pharmacology |
| Volume | 47 |
| Issue | 2 |
| Page Numbers | 156-165 |
| Abstract | There are no reports of studies that evaluate if methyl tertiary-butyl ether (MTBE) exposure causes cancer in humans. This evaluation of MTBE carcinogenicity is based on the results of animal studies. A weak tumorigenic response was reported for both MTBE and TBA in one tumor type (kidney) in male rats, for MTBE in one other tumor type (testicular) in male rats, for MTBE in one tumor type (liver) in female mice, and for TBA in one tumor type (thyroid) in female mice. The weight of the evidence does not support a genotoxic mode of action (MOA). Non-genotoxic MOAs have been demonstrated or suggested that correspond to the weak tumorigenic responses. These MOAs either do not occur in humans or humans are much less susceptible to these effects. It is, therefore, unlikely that humans would be exposed to sufficient levels of MTBE to cause these tumorigenic responses. |
| Doi | 10.1016/j.yrtph.2006.09.003 |
| Pmid | 17084497 |
| Wosid | WOS:000244766200003 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB. tertiary is italicized.Regul. Toxicol. Pharmacol. 47: 156-165. |
| Is Public | Yes |
| Language Text | English |
| Keyword | MTBE; TBA; Carcinogenicity; Mode of action; Nephropathy; Genotoxicity |
| Is Qa | No |