Particulate air pollution, progression, and survival after myocardial infarction
Zanobetti, A; Schwartz, J
HERO ID
91247
Reference Type
Journal Article
Year
2007
Language
English
PMID
| HERO ID | 91247 |
|---|---|
| In Press | No |
| Year | 2007 |
| Title | Particulate air pollution, progression, and survival after myocardial infarction |
| Authors | Zanobetti, A; Schwartz, J |
| Journal | Environmental Health Perspectives |
| Volume | 115 |
| Issue | 5 |
| Page Numbers | 769-775 |
| Abstract | OBJECTIVE: Several studies have examined the effect of particulate pollution (PM) on survival in general populations, but less is known about susceptible groups. Moreover, previous cohort studies have been cross-sectional and subject to confounding by uncontrolled differences between cities. DESIGN: We investigated whether PM was associated with progression of disease or reduced survival in a study of 196,000 persons from 21 U.S. cities discharged alive following an acute myocardial infarction (MI), using within-city between-year exposure to PM. We constructed city-specific cohorts of survivors of acute MI using Medicare data between 1985 and 1999, and defined three outcomes on follow-up: death, subsequent MI, and a first admission for congestive heart failure (CHF). Yearly averages of PM(10) (particulate matter with aerodynamic diameter < 10 microm) were merged to the individual annual follow-up in each city. We applied Cox's proportional hazard regression model in each city, with adjustment for individual risk factors. In the second stage of the analysis, the city-specific results were combined using a meta-regression. RESULTS: We found significant associations with a hazard ratio for the sum of the distributed lags of 1.3 [95% confidence interval (CI), 1.2-1.5] for mortality, a hazard ratio of 1.4 (95% CI, 1.2-1.7) for a hospitalization for CHF, and a hazard ratio of 1.4 (95% CI, 1.1-1.8) for a new hospitalization for MI per 10 microg/m(3) PM(10). CONCLUSIONS: This is the first long-term study showing a significant association between particle exposure and adverse post-MI outcomes in persons who survived an MI. |
| Doi | 10.1289/ehp.9201 |
| Pmid | 17520066 |
| Wosid | WOS:000246159900038 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.Particulate air pollution, progression, and survival after myocardial infarction.Environ. Health Perspect. 115: 769-775. |
| Is Public | Yes |
| Language Text | English |
| Keyword | air pollution; epidemiology; heart diseases; myocardial infarction; survival |
| Is Qa | No |
| Relationship(s) |
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