Ozone, oxidant defense genes and risk of asthma during adolescence
Islam, T; Mcconnell, R; Gauderman, WJ; Avol, E; Peters, JM; Gilliland, FD
HERO ID
97348
Reference Type
Journal Article
Year
2008
Language
English
PMID
| HERO ID | 97348 |
|---|---|
| In Press | No |
| Year | 2008 |
| Title | Ozone, oxidant defense genes and risk of asthma during adolescence |
| Authors | Islam, T; Mcconnell, R; Gauderman, WJ; Avol, E; Peters, JM; Gilliland, FD |
| Journal | American Journal of Respiratory and Critical Care Medicine |
| Volume | 177 |
| Issue | 4 |
| Page Numbers | 388-395 |
| Abstract | RATIONALE: Although oxidative stress is a cardinal feature of asthma, the roles of oxidant air pollutants and antioxidant genes heme oxygenase 1 (HMOX-1), catalase (CAT), and manganese superoxide dismutase (MNSOD) in asthma pathogenesis have yet to be determined. OBJECTIVES: We hypothesized that the functional polymorphisms of HMOX-1 ([GT](n) repeat), CAT (-262C>T -844C>T), and MNSOD (Ala-9Val) are associated with new-onset asthma, and the effects of these variants vary by exposure to ozone, a potent oxidant air pollutant. Methods: We assessed this hypothesis in a population-based cohort of non-Hispanic (n = 1,125) and Hispanic white (n = 586) children who resided in 12 California communities and who were followed annually for 8 years to ascertain new-onset asthma. MEASUREMENTS AND MAIN RESULTS: Air pollutants were continuously measured in each of the study communities during the 8 years of study follow-up. HMOX-1 "short" alleles (<23 repeats) were associated with a reduced risk for new-onset asthma among non-Hispanic whites (hazard ratio [HR], 0.64; 95% confidence interval [CI], 0.41-0.99). This protective effect was largest in children residing in low-ozone communities (HR, 0.48; 95% CI, 0.25-0.91) (interaction P value = 0.003). Little evidence for an association with HMOX-1 was observed among Hispanic children. In contrast, Hispanic children with a variant of the CAT-262 "T" allele (CT or TT) had an increased risk for asthma (HR, 1.78; P value = 0.01). The effects of these polymorphisms were not modified by personal smoking or secondhand-smoke exposure. CONCLUSIONS: Functional promoter variants in CAT and HMOX-1 showed ethnicity-specific associations with new-onset asthma. Oxidant gene protection was restricted to children living in low-ozone communities. |
| Doi | 10.1164/rccm.200706-863OC |
| Pmid | 18048809 |
| Wosid | WOS:000253222800007 |
| Url | https://www.atsjournals.org/doi/10.1164/rccm.200706-863OC |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science 000253222800007 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Adolescent; Air Pollutants/analysis; Alleles; Asthma/ethnology/*genetics/metabolism; Catalase/*genetics/metabolism; Cohort Studies; Environmental Monitoring; Female; Gene Expression Regulation; Genotype; Heme Oxygenase-1/*genetics; Hispanic Americans/statistics & numerical data; Humans; Incidence; Inhalation Exposure/analysis/prevention & control; Male; Oxidative Stress/genetics; Ozone/analysis; *Polymorphism, Genetic; Prognosis; Risk Assessment; Severity of Illness Index; Superoxide Dismutase/*genetics/metabolism |
| Is Qa | No |
| Relationship(s) |
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