Source apportionment of particulate matter in the U.S. and associations with lung inflammatory markers
Duvall, RM; Norris, GA; Dailey, LA; Burke, JM; Mcgee, JK; Gilmour, MI; Gordon, T; Devlin, RB
HERO ID
97969
Reference Type
Journal Article
Year
2008
Language
English
PMID
| HERO ID | 97969 |
|---|---|
| In Press | No |
| Year | 2008 |
| Title | Source apportionment of particulate matter in the U.S. and associations with lung inflammatory markers |
| Authors | Duvall, RM; Norris, GA; Dailey, LA; Burke, JM; Mcgee, JK; Gilmour, MI; Gordon, T; Devlin, RB |
| Journal | Inhalation Toxicology |
| Volume | 20 |
| Issue | 7 |
| Page Numbers | 671-683 |
| Abstract | Size-fractionated particulate matter (PM) samples were collected from six U.S. cities and chemically analyzed as part of the Multiple Air Pollutant Study. Particles were administered to cultured lung cells and the production of three different proinflammatory markers was measured to explore the association between the health effect markers and PM. Ultrafine, fine, and coarse PM samples were collected between December 2003 and May 2004 over a 4-wk period in each city. Filters were pooled for each city and the PM samples were extracted then analyzed for trace metals, ions, and elemental carbon. Particle extracts were applied to cultured human primary airway epithelial cells, and the secreted levels of interleukin-8 (IL-8), heme oxygenase-1, and cyclooxygenase-2 were measured 1 and 24 h following exposure. Fine PM sources were quantified by the chemical mass balance (CMB) model. The relationship between toxicological measures, PM sources, and individual species were evaluated using linear regression. Ultrafine and fine PM mass were associated with increases in IL-8 (r2 = .80 for ultrafine and r2 =.52 for fine). Sources of fine PM and their relative contributions varied across the sampling sites and a strong linear association was observed between IL-8 and secondary sulfate from coal combustion (r2 =.79). Ultrafine vanadium, lead, copper, and sulfate were also associated with increases in IL-8. Increases in inflammatory markers were not observed for coarse PM mass and source markers. These findings suggest that certain PM size fractions and sources are associated with markers of lung injury or inflammation. |
| Doi | 10.1080/08958370801935117 |
| Pmid | 18464055 |
| Wosid | WOS:000256086100005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science 000256086100005 |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |
| Relationship(s) |
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