Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice
Fujitani, T; Ohyama, K; Hirose, A; Nishimura, T; Nakae, D; Ogata, A
HERO ID
1071956
Reference Type
Journal Article
Year
2012
Language
English
PMID
| HERO ID | 1071956 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice |
| Authors | Fujitani, T; Ohyama, K; Hirose, A; Nishimura, T; Nakae, D; Ogata, A |
| Journal | Journal of Toxicological Sciences |
| Volume | 37 |
| Issue | 1 |
| Page Numbers | 81-89 |
| Abstract | A possible teratogenicity of multi-wall carbon nanotube (MWCNT) was assessed using ICR mice. MWCNTs were suspended in 2% carboxymethyl cellulose and given intraperitoneally or intra-tracheally to pregnant ICR mice on day 9 of the gestation. All fetuses were removed from the uterus on day 18 of the gestation, and were examined for external and skeletal anomalies. In the intraperitoneal study, various types of malformation were observed in all MWCNT-treated groups (2, 3, 4 and 5 mg/kg body weight, intraperitoneal). In contrast, such malformations were observed in groups given 4 or 5 mg/kg body weight, but not in that treated with 3 mg/kg in the intratracheal study. In either study, the number of litters having fetuses with external malformation and that of litters having fetuses with skeletal malformations were both increased in proportion to the doses of MWCNT. The present results are the first to report that MWCNT possesses the teratogenicity at least under the present experimental conditions. Mechanism(s) to result such malformations is yet unclear and further experiment is necessary. |
| Pmid | 22293413 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |