New tigliane-type diterpenoids from Euphorbia aellenii Rech. f. with immunomodulatory activity
Ghanadian, M; Ayatollahi, AM; Mesaik, MA; Afsharypuor, S; Abdalla, OM; Kobarfard, F
| HERO ID | 1455097 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | New tigliane-type diterpenoids from Euphorbia aellenii Rech. f. with immunomodulatory activity |
| Authors | Ghanadian, M; Ayatollahi, AM; Mesaik, MA; Afsharypuor, S; Abdalla, OM; Kobarfard, F |
| Volume | 6 |
| Issue | 1 |
| Page Numbers | 35-41 |
| Abstract | The cytotoxic chloroform fraction of Euphorbia aellenii Rech. F. (Euphorbiaceae) afforded two new phorbol diterpenoids: 4-deoxy-4α-phorbol-12-(2,3-dimethyl) butyrate-13-isobutyrate and 17-hydroxy-4-deoxy-4α-phorbol-12-(2,3-dimethyl) butyrate-13-isobutyrate. Their structures were elucidated by NMR and other spectroscopic methods. The immunomodulating potentials of the isolated compounds were tested using standard proliferation and chemiluminescence assays. Compound 2 showed moderate inhibitory activity against both T-cell proliferation and reactive oxygen species (ROS) production in whole blood with IC50 of 14.0 ± 0.57 and 44.1 ± 3.8 μg/ml, respectively, while compound 1 was relatively inactive with IC50 >50 μg/mL for T-cell proliferation, and >100 μg/mL for ROS. |
| Pmid | 22049276 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Research in pharmaceutical sciences ISSN: 1735-9414 |
| Is Public | Yes |
| Language Text | English |