Fragrance material review on 2-methyl-4-phenyl-2-butanol
Scognamiglio, J; Jones, L; Letizia, CS; Api, AM
| HERO ID | 1455102 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2012 |
| Title | Fragrance material review on 2-methyl-4-phenyl-2-butanol |
| Authors | Scognamiglio, J; Jones, L; Letizia, CS; Api, AM |
| Journal | Food and Chemical Toxicology |
| Volume | 50 Suppl 2 |
| Issue | SUPPL. 2 |
| Page Numbers | S184-S188 |
| Abstract | A toxicologic and dermatologic review of 2-methyl-4-phenyl-2-butanol when used as a fragrance ingredient is presented. 2-methyl-4-phenyl-2-butanol is a member of the fragrance structural group Aryl Alkyl Alcohols and is a tertiary alcohol. The AAAs are a structurally diverse class of fragrance ingredients that includes primary, secondary, and tertiary alkyl alcohols covalently bonded to an aryl (Ar) group, which may be either a substituted or unsubstituted benzene ring. The common structural element for the AAA fragrance ingredients is an alcohol group -C-(R1)(R2)OH and generically the AAA fragrances can be represented as an Ar-C-(R1)(R2)OH or Ar-Alkyl-C-(R1)(R2)OH group. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 2-methyl-4-phenyl-2-butanol were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, and skin sensitization data. A safety assessment of the entire Aryl Alkyl Alcohols will be published simultaneously with this document; please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all Aryl Alkyl Alcohols in fragrances. assessment of aryl alkyl alcohols when used as fragrance ingredients. |
| Doi | 10.1016/j.fct.2011.10.020 |
| Pmid | 22036982 |
| Wosid | WOS:000309574800019 |
| Url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865763510&doi=10.1016%2fj.fct.2011.10.020&partnerID=40&md5=7a90249cee7060767cd31e890db99530 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000309574800019 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Fragrance material 2-methyl-4-phenyl-2-butanol; Review |