Aggregation of two carboxylic derivatives of porphyrin and their affinity to bovine serum albumin
Yin, YB; Wang, YN; Ma, HB
| HERO ID | 1461570 |
|---|---|
| In Press | No |
| Year | 2006 |
| Title | Aggregation of two carboxylic derivatives of porphyrin and their affinity to bovine serum albumin |
| Authors | Yin, YB; Wang, YN; Ma, HB |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Volume | 64 |
| Issue | 4 |
| Page Numbers | 1032-1038 |
| Abstract | Aggregation of two porphyrin derivatives with carboxylic groups, 4-oxo-4-((4-(10,15,20-triphenyl-21H,23H-porphin-5-yl)phenyl)amino)butanoic acid (MAC) and 4,4',4'',4'''-[21H,23H-porphine-5,10,15,20-tetrayltetrakis(4,1-phenyleneimino)]tetrakis(4-oxo-butanoic acid) (TA4C), and their affinity to bovine serum albumin were investigated via absorption spectrometry, (1)H NMR and fluorescence spectrometry. MAC and its complexes with beta-cyclodextrin could form aggregates in an aqueous solution while TA4C was self-associated loosely. From the absorbance profiles of MAC in the titration of bovine serum albumin, hypochromicity was observed without any shift of the maximum absorbance wavelength. In both absorption spectra of TA4C in aqueous solutions and in solid state, three Q bands appeared in the visible region. In the measurements of absorption and fluorescence spectra upon titration of BSA, some spectral changes of TA4C were observed. The whole procedure of titration could be divided into three successive stages. The three-banded profiles of TA4C might be explained according to a loose dimer model. |
| Doi | 10.1016/j.saa.2005.09.012 |
| Pmid | 16458065 |
| Wosid | WOS:000238523100029 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000238523100029 |
| Is Public | Yes |
| Language Text | English |
| Keyword | aggregation; binding modes; three-banded Q bands; fluorescence; absorption spectrum |