Schisandra N-butanol extract improves synaptic morphology and plasticity in ovarectomized mice
Yang, M; Cai, Z; Xiao, P; Li, C
| HERO ID | 1462615 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Schisandra N-butanol extract improves synaptic morphology and plasticity in ovarectomized mice |
| Authors | Yang, M; Cai, Z; Xiao, P; Li, C |
| Journal | Neural Regeneration Research |
| Volume | 7 |
| Issue | 18 |
| Page Numbers | 1365-1369 |
| Abstract | Preliminary work by our research team revealed that Schisandra, a renowned traditional Chinese medicine, causes learning and memory improvements in ovariectomized mice. This activity was attributed to active ingredients extracted with N-butyl alcohol, named Schisandra N-butanol extract. In this study, ovariectomized mice were pretreated with Schisandra N-butanol extract given by intragastric administration. This treatment led to the enhancement of learning, and an increase in hippocampal CA1 synaptic, surface and postsynaptic density. A decrease in the average size of the synaptic active zone was also observed. These experimental findings showing that Schisandra N-butanol extract improved synaptic morphology indicate an underlying mechanism by which the ability of learning is enhanced in ovariectomized mice. |
| Doi | 10.3969/j.issn.1673-5374.2012.18.001 |
| Pmid | 25657668 |
| Wosid | WOS:000306301300001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000306301300001 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Schisandra N-butanol extract; ovariectomy; mice; behavioral learning; hippocampal CA1; synaptic morphology; synaptic density; neural regeneration |