Mussel-inspired polydopamine coated mesoporous silica nanoparticles as pH-sensitive nanocarriers for controlled release
Zheng, Q; Lin, T; Wu, H; Guo, L; Ye, P; Hao, Y; Guo, Q; Jiang, J; Fu, F; Chen, G
| HERO ID | 2896711 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Mussel-inspired polydopamine coated mesoporous silica nanoparticles as pH-sensitive nanocarriers for controlled release |
| Authors | Zheng, Q; Lin, T; Wu, H; Guo, L; Ye, P; Hao, Y; Guo, Q; Jiang, J; Fu, F; Chen, G |
| Journal | International Journal of Pharmaceutics |
| Volume | 463 |
| Issue | 1 |
| Page Numbers | 22-26 |
| Abstract | A novel pH-sensitive controlled release system is proposed by using mussel-inspired polydopamine (PDA) coated mesoporous silica nanoparticles (MSNs) as nanocarriers.MSNs with a large pore diameter are synthesized by using 1,3,5-trimethylbenzene as a pore-expanding agent and are modified with a PDA coating by virtue of oxidative self-polymerization of dopamine in neutral pH. PDA coated MSNs are characterized by FTIR, TEM, N2 adsorption and XPS techniques. The PDA coating can work as pH-sensitive gatekeepers to control the release of drug molecules from MSNs in response to the pH-stimulus. Doxorubicin (DOX, an anticancer drug) can be released in the acid media and blocked in the neutral media. (C) 2014 Elsevier B.V. All rights reserved. |
| Doi | 10.1016/j.ijpharm.2013.12.045 |
| Pmid | 24393764 |
| Wosid | WOS:000330581700003 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Controlled release; Mesoporous silica nanoparticles; Polydopamine; Drug delivery |