Ames metabolic activation test to assess the potential mutagenic effect of und no. 49 with cover letter dated 031290
HERO ID
787683
Reference Type
Technical Report
Subtype
TSCA Submission
Year
1990
Language
English
| HERO ID | 787683 |
|---|---|
| Material Type | TSCA Submission |
| Year | 1990 |
| Title | Ames metabolic activation test to assess the potential mutagenic effect of und no. 49 with cover letter dated 031290 |
| Authoring Organization | Huntingdon Research Center |
| Publisher Text | BASF Corporation |
| City | Wyandotte, MI |
| Abstract | 1,2,5,6,9,10-Hexabromocyclododecane was evaluated for mutagenicity in vitro in the TA98, TA100, and TA1535 strains of Salmonella typhimurium, both in the presence and absence of Arochlor-induced rat liver S-9 metabolic activation. Bacterial cultures with and without metabolic activation were tested at concentrations of 0, 10, 100, 1000, and 10000 ug/plate; the test compound formed a precipitate at 10000 ug/plate, possibly affecting the accuracy of the test. The treatment did not increase the frequency of histidine revertants, either with or without metabolic activation, indicating that the test compound was not mutagenic in Salmonella under the conditions of this assay. Positive control treatment with 10 ug/plate beta- naphthylamine or 20 ug/plate 2-aminoanthracene produced the expected large increases in the frequency of histidine revertants. The document summarizes this study, and no further information is available regarding experimental method or results. |
| Report Number | TSCATS/406642. OTS0522948. 86900000385 |
| Ntis Number | OTS0522948 |
| Tscats Number | TSCATS/406642 |
| Url | https://ntrl.ntis.gov/NTRL/dashboard/searchResults.xhtml?searchQuery=OTS0522948 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Note: ToxNet and NTIS have the title as: "Ames metabolic activation test to assess the potential mutagenic effect of und no. 49 with cover letter dated 031290." (Should have been "compound" not "und") |
| Is Public | Yes |
| Language Text | English |
| Keyword | hexabromocyclododecane (3194-55-6); health effects; genotoxicity; gene mutations; bacteria; in vitro; 3194-55-6 |
| Relationship(s) |
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