[Effect of sodium butyrate on apoptosis and stromal interaction molecule and Orai1 activity in human colon cancer HCT-116 cells in vitro]
Sun, S; Li, W; Chen, S; Zhang, H; Yu, S; Zhang, M; Zou, F
HERO ID
1455006
Reference Type
Journal Article
Year
2012
Language
chi
PMID
| HERO ID | 1455006 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | [Effect of sodium butyrate on apoptosis and stromal interaction molecule and Orai1 activity in human colon cancer HCT-116 cells in vitro] |
| Authors | Sun, S; Li, W; Chen, S; Zhang, H; Yu, S; Zhang, M; Zou, F |
| Journal | Nan Fang Yi Ke Da Xue Xue Bao / Journal of Southern Medical University |
| Volume | 32 |
| Issue | 2 |
| Page Numbers | 189-192 |
| Abstract | <strong>OBJECTIVE: </strong>To investigate the mechanism underlying sodium butyrate (NaB)-induced apoptosis of a human colon cancer cell line HCT-116.<br /><br /><strong>METHODS: </strong>The apoptosis of HCT-116 cells induced by NaB was confirmed by hoechst33342 staining and AnnexinV+ PI assay. The changes in the intracellular localization of stromal interaction molecule (STIM1) and Orai1 following NaB treatment were detected by immunofluorescence technique. Western blotting was used to investigate the protein expression levels of STIM1 and Orai1.<br /><br /><strong>RESULTS: </strong>NaB induced apoptosis and caused translocation and colocalization of STIM1 and Orai1 in HCT-116 cells.<br /><br /><strong>CONCLUSION: </strong>The apoptosis of human colon cancer cells induced by NaB is correlated to the redistribution of STIM1 and Orai1. |
| Pmid | 22381755 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | chi |